As the majority of patients (n=step one66) were recruited in the first year, we compared the baseline characteristics of recruited patients to the overall eligible clinic population in the major recruitment centre (the Hospital for Sick Children). Patients participating in the study were younger (11.8±dos.9 years versus 13.4±3.3 years, p<0.0005) and had higher lung function (FEV1 85.6±17.4% pred versus 67.2±23.0% pred, p<0.0001) than patients not participating in the study (n=67). There was no significant difference in baseline FEV1 (p=0.5048) or V?O2max (p=0.7126) between patients from the two paediatric centres (data not shown).
1, mucoid P. aeruginosa and CFRD, overall FEV1 decreased at a mean± sd rate of 1.63±0.08% per year (p<0.0001) and HPA increased at a mean± sd rate of 0.28±0.03 h·day ?1 per year (p<0.0001) over the study period. There was a significant positive correlation between rates of change of activity level and change in FEV1 decline, indicating that an increase in activity was associated with a slower rate of decline in lung function over the study period (r=0.19, p<0.007).
Participants were divided into high (above the mean rate of change of activity) and low (below the mean rate of change of activity) groups. table 3 indicates that all evaluated potential confounder variables were evenly distributed between the two groups. The high group had a rate of increase in HPA of 0.59 h·day ?1 per year, while the low group had a https://www.datingranking.net/escort-directory/irving rate of decline of activity of 0.15 h·day ?1 per year over the study period. Mixed model analysis results are presented in table 4 and indicate that FEV1 was significantly associated with baseline FEV1 (p=0.0001), CFRD (p=0.0452) and change in activity level over time, such that the rate of decline of FEV1 was less steep for the high group (-1.39% pred per year) compared to the low group (-1.90% pred per year) (p=0.0001). Nastavi sa čitanjem