H. pylori have been associated with coronary heart disease . Hyperhomocysteinemia secondary to folate and Ba dozen deficiency might be the link between H. pylori infection and coronary heart disease. Reduced folate and B12 absorption can occur in an environment of increased gastric juice pH. This would result in a reduced folate status leading to decreased activity of methionine synthase and increased serum concentration of homocysteine. Homocysteine is toxic to endothelial cells and a risk factor for atherosclerosis . Since 199cuatro, several studies have been published on B12 and folate levels in H. pylori infected patients with conflicting results [6, 12, 13]. A review based upon more than two dozen studies dealing with H. pylori infection and vitamin B12 status and H. pylori infection and hyperhomocysteinemia or both failed to show any clear relationship among H. pylori infection, B12 deficiency and hyperhomocysteinemia . Hence the objective of this study was to investigate the relationship between folate, vitamin B12 and homocysteine levels and the impact of H. pylori infection on this relationship in patients with FD.
One hundred and thirty-two consecutive adult males and non-pregnant females with symptoms of dyspepsia who were undergoing gastroscopy were enrolled in the study at the Aga Khan University Hospital (AKUH) from . Prior written informed consent was obtained from all the study patients. FD was defined as the presence of one or more symptoms of epigastric pain, postprandial bloating, epigastric burning and/or early satiety that are considered to originate from the gastroduodenal region in the absence of any organic, systemic or metabolic disease. Nastavi sa čitanjem